| 双环及三环核苷的合成 |
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| 引用本文： | 刘云华,张卫红,冯亚青,孟祥启.双环及三环核苷的合成[J].化学通报,2005,68(12):881-888. |
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| 作者姓名： | 刘云华 张卫红 冯亚青 孟祥启 |
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| 作者单位： | 天津大学化工学院,天津,300072;天津大学化工学院,天津,300072;天津大学化工学院,天津,300072;天津大学化工学院,天津,300072 |
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| 基金项目： | 天津市自然科学基金资助项目（05YFJMJC09600） |
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| 摘 要： | 摘要综述了天然双环核苷、抗病毒构效研究中的双环核苷和反义寡核苷酸领域中双环及三环核苷的合成研究进展，介绍了常规官能团转化法及近年来出现的自由基环合、1，3-偶极环加成和烯烃复分解等新方法。
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| 关 键 词： | 双环核苷 三环核苷 自由基环合 1 3-偶极环加成 烯烃复分解 |
| 收稿时间： | 2005-05-08 |
| 修稿时间： | 2005-05-082005-07-07 |
Synthesis of Bi- and Tri-cyclic Nucleosides |
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| Liu Yunhua, Zhang Weihong , Feng Yaqing, Meng Xiangqi.Synthesis of Bi- and Tri-cyclic Nucleosides[J].Chemistry,2005,68(12):881-888. |
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| Authors: | Liu Yunhua Zhang Weihong Feng Yaqing Meng Xiangqi |
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| Institution: | School of Chemical Engineering , Tianjin University, Tianjin 300072 |
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| Abstract: | This paper reviewed the research in the synthesis of bicyclic nucleosides naturally occurring and in antiviral structure-activity research, as well as bi- and tri-cyclic nucleosides in antisense oligonucleotides. The method of functional group conversion and new methods of radical cyclization, 1,3-dipolar cycloaddition, ring-closing metathesis were involved. |
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| Keywords: | Bicyclic nucleosides Tricyclic nucleosides Radical cyclization 1 3-Dipolar cycloaddition Ringclosing metathesis |
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