| The Antagonistic Effect of Cholecystokinin Octapeptide (CCK-8) on Opioid Effects in Cardiovascular Activities Was Mediated by CCK-B Receptor |
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| 作者姓名： | 梅林 韩济生 |
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| 作者单位： | Department of Physiology，Beijing Medical University，Beijing 100083，PRC，Department of Physiology，Beijing Medical University，Beijing 100083，PRC |
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| 基金项目： | Project supported by the National Natural Science Foundation of China. |
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| 摘 要： | Previous studies have shown that CCK-8 has distinct antiopioid effect in the central sites related with pain control and blood pressure control. The aim of this study was to explore the receptor mechanism by which CCK-8 antagonized the depressor effect of u- and k-opioid(?) agonists, and to observe whether CCK-8 could antagonize the depressor effect induced by muscimol, a nonopioid substance. The results showed that (i) The antagonistic effect of CCK-8 on opioid-induced hypotension could be blocked by intrathecal (i.t.) administration of CCK-B antagonist L-365, 260 at nanogram doses, or by CCK-A antagonist devazepide at doses 20—40 times higher than L-365, 260, indicating that it was the CCK-B receptor which mediates the antiopioid effect. (ⅱ) The depressor effect induced by intrathecal muscimol, a GABA agonist, was blocked neither by naloxone nor by CCK-8, supporting the notion that CCK-8 is an endogenous opioid antagonist rather than a universal anti-hypotension agent.
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The Antagonistic Effect of Cholecystokinin Octapeptide (CCK-8) on Opioid Effects in Cardiovascular Activities Was Mediated by CCK-B Receptor |
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| MEI Lin HAN Ji-Sheng.The Antagonistic Effect of Cholecystokinin Octapeptide (CCK-8) on Opioid Effects in Cardiovascular Activities Was Mediated by CCK-B Receptor[J].Science in China(Chemistry),1993(7). |
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| Authors: | MEI Lin HAN Ji-Sheng |
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| Abstract: | |
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| Keywords: | cholecystokinin octapeptide opioid peptides blood pressure L-365 260 devazepide proglumide muscimol |
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