Microwave-promoted facile and efficient preparation of N-(alkoxycarbonylmethyl) nucleobases--building blocks for peptide nucleic acids |
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| Authors: | Qu Guirong Zhang Zhiguang Guo Haiming Geng Mingwei Xia Ran |
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| Institution: | College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, PR China. quguir@163.com |
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| Abstract: | A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation. |
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