| Regioselective ring opening of epoxides using NH4SCN/silica sulfuric acid： An efficient approach for the synthesis of β-hydroxy thiocyanate under solvent-free conditions |
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| 作者姓名： | Ali R. Kiasat Maryam Zayadi Mehdi Fallah Mehrjardi |
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| 作者单位： | Chemistry Department, College of Science, Shahid Chamran University, Ahvaz 61357-4-3169, Iran |
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| 基金项目： | Acknowledgments We are thankful to the University of Shahid Chamran Research Council for the partial support of this work. |
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| 摘 要： | Silica sulfuric acid was developed as a stable and efficient heterogeneous catalyst in organic synthesis. This solid acid catalyzed the regioselective ring opening of epoxides by thiocyanate anion to give thiocyanohydrins as key intermediates in agricultural and pharmaceutical chemistry in high yields under solvent-free conditions.
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| 关 键 词： | 二氧化硅 硫酸 硫代氰酸盐滴定法 β-氢氧基 硫脲硫氰酸盐 环氧化物 |
| 收稿时间： | 2 January 2008 |
Regioselective ring opening of epoxides using NH4SCN/silica sulfuric acid： An efficient approach for the synthesis of β-hydroxy thiocyanate under solvent-free conditions |
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| Ali R. Kiasat Maryam Zayadi Mehdi Fallah Mehrjardi.Regioselective ring opening of epoxides using NH4SCN/silica sulfuric acid： An efficient approach for the synthesis of β-hydroxy thiocyanate under solvent-free conditions[J].Chinese Chemical Letters,2008,19(6):665-668. |
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| Authors: | Ali R Kiasat Maryam Zayadi Mehdi Fallah Mehrjardi |
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| Institution: | Chemistry Department, College of Science, Shahid Chamran University, Ahvaz 61357-4-3169, Iran |
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| Abstract: | Silica sulfuric acid was developed as a stable and efficient heterogeneous catalyst in organic synthesis.This solid acid catalyzed the regioselective ring opening of epoxides by thioeyanate anion to give thiocyanohydrins as key intermediates in agricultural and pharmaceutical chemistry in high yields under solvent-free conditions. |
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| Keywords: | Silica sulfuric acid Thiocyanohydrins β-Hydroxy thiocyanate Epoxide Solvent-free |
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