Theory of DNA condensation in the presence of stretching force: Zimm-Bragg model |
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Authors: | Y. Sh. Mamasakhlisov |
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Affiliation: | 1.Yerevan State University,Yerevan,Armenia |
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Abstract: | A theory of DNA condensation by multivalent cations in the presence of an external stretching force is presented. It is shown that in the mean-field approximation the system is described by the Zimm-Bragg model with effective parameters of growth of ordered phase and cooperativity. Within the frames of the proposed model the experimental results on stretching of a double-stranded DNA of λ-phage are interpreted. Possible scenarios of homo- and heteropolymeric behavior of DNA during condensation are analyzed. A possible mechanism restricting the growth of linear size of DNA is proposed. |
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