Macrocyclic lactones as a source for radiohalogenated fatty acid analogs and their precursors |
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| Authors: | H. Dougan D. M. Lyster J. S. Vincent |
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| Affiliation: | (1) TRIUMF, University of British Columbia, Vancouver, B. C., (Canada);(2) Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B. C., (Canada) |
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| Abstract: | A simple approach is presented whereby omega halogenated fatty acids can be obtained from macrocyclic musk lactones which are industrially available. While providing a secure source of 16-iodo-hexadecanoic acid and 17-iodo-heptadecanoic acid, the scheme allows ready access to a large number of untried fatty acid analogs. Examples presented are 16-iodo-hexadecanoic acid. 16-iodo-7-hexadecenoic acid. 16-iodo-12-oxa-hexadecanoic acid, 15-iodo-pentadecanoic acid, and 15-iodo-12-keto-pentadecanoic acid. |
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