| Molecular modeling on Zn(II) binding modes of Alzheimer's amyloid β-peptide in insoluble aggregates and soluble complexes |
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| 作者姓名： | HAN Daxiong & YANG Pin Institute of Molecular Science Chemical Biology and Molecular Engineering Laboratory of Ministry of Education Shanxi University Taiyuan China |
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| 作者单位： | HAN Daxiong & YANG Pin Institute of Molecular Science,Chemical Biology and Molecular Engineering Laboratory of Ministry of Education,Shanxi University,Taiyuan 030006,China |
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| 摘 要： | Alzheimers disease (AD) is a progressive neu-rodegenerative illness relative to aging. One of the major pathological characters is that senile plaques (SP) occur in the brains of patients. Amyloid b-peptide (Ab) is the major constituent of senile plaques. The peptide is produced from a precursor membrane pro-tein (APP) by normal proteolytic processing and is released into extracellular fluids as a soluble peptide of 39—42 amino acids1,2]. For AD patients, Ab ag-gregates and accumulates …
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| 收稿时间： | 19 August 2006 |
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