Random peptide synthesis using immobilized enzymes in high concentrations of organic solvents |
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Authors: | W. P. Vann H. H. Weetall |
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Affiliation: | 1. Corning Glass Works Sullivan Science Park Corning, 14870, New York
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Abstract: | Trypsin, leucine aminopeptidase, and carboxypeptidase B were separately immobilized on controlled pore glass and reacted with a dipeptide substrate in high concentrations of either acetone or 1-propanol. Hydrolytic activity was demonstrated and evidence for the possible synthesis of peptide polymer is presented. Directed synthesis using amino acids and blocked amino acids as substrates was not successful. |
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