芳香型螺双内酯二胺的合成

以对硝基甲苯和多聚甲醛为原料,经过两种途径合成了二氨基芳香型螺双内酯--6,6′-二氨基-3,3′-螺双苯酞.发现二(2-甲基-5-硝基苯基)甲烷在酸性体系中经氧化反应可高收率地得到二硝基螺双内酯,还原二硝基螺双内酯时发现,在低极性溶剂中主要生成一种稳定的芳香型羟胺类化合物--6,6′-二羟氨基-3,3′-螺双苯酞,在高极性溶剂中主要生成6,6′-二氨基-3,3′-螺双苯酞.通过¹HNMR,¹³CNMR,IR,MS及元素分析确证了二氨基螺双内酯及其中间产物的结构

Synthesis of Aromatic Diaminospirodilactone

Anew kind of aromatic diaminospirodilactone, i.e. 6,6′-diamino-3,3′-spirobiphthalide, was synthesized through multistep reactions from p nitrotoulene and paraformaldehyde.It was found that dinitrospirolactone could be synthesized directly in the acid system through oxidation reaction with a high yield.The increase of solvent polarity leads to an increase of reduction yield of dinitrolactone.The resulting intermediates6,6′- dihydroxylamino-3,3′ spirobiphthalide and6-amino-6′-hydroxylanimo-3,3′ spirobiphthalide were steady aromatic hydroxylamine.The structures of6,6′-diamino-3,3′-spirobiphthalide and its intermediates were confirmed by¹H NMR, ¹³C NMR, MS, IRand elemental analyses