Some physico-chemical characteristics of amino-acid derivatives containing rest of 1,2,4-triazole-3,4-di-substituted with potential antitumoral activity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Some physico-chemical characteristics of amino-acid derivatives containing rest of 1,2,4-triazole-3,4-di-substituted with potential antitumoral activity

Authors:	Corina Cheptea Valeriu Sunel Shardi Manahedji Ardeshir Ana Cezarina Morosanu

Institution:	1. Department of Biomedical Sciences, Grigore T. Popa University of Medicine and Pharmacy of Iasi, Faculty of Medical Bioengineering, Iasi, Romania;2. Faculty of Chemistry, Al. I. Cuza University of Iasi, Iasi, Romania;3. Faculty of Physics, Al. I. Cuza University of Iasi, Iasi, Romania

Abstract:	Abstract Dipeptide derivatives from p-aminobenzoyl-phenylglycine and p-aminobenzoyl-phenylalanine were grafted on 1,2,4-triazole heterocycle in order to get new substances with potential biological activity. The compounds synthetized and characterized in this paper have a structure that fits in the antimetabolites category, products used to treat malignant tumors. The presence of several bioactive groups in the same molecule permits us to study the chemical structure - biological activity correlation based on computational analyses using SPARTAN’14 software. Some correlations between the molecular parameters established with Spartan’14 software are evidenced in this paper.

Keywords:	antimetabolites dipeptides 1 2 4-triazole heterocycle NMR and FTIR Spectroscopy p-aminobenzoyl-phenylalanine p-aminobenzoyl-phenylglycine Spartan 14 software