Terezine E,bioactive prenylated tryptophan analogue from an endophyte of Centaurea stoebe |
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| Authors: | Randa Abdou Samah Shabana |
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| Institution: | 1. Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt;2. Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Mecca, Kingdom of Saudi Arabia;3. Department of Pharmacognosy, Faculty of Pharmacy, Misr University for Science &4. Technology (MUST), Gizam, Egypt |
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| Abstract: | AbstractFungal endophytes are considered promising sources of new bioactive natural products. In this study, a Mucor sp. has been isolated as an endophyte from the medicinal plant Centaurea stoebe. Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains. |
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| Keywords: | Terezine E endophyte cytotoxic antimicrobial |
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