New flavonoid and stilbene derivatives from the fruits of Macaranga balansae |
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| Authors: | Huong Doan Thi Mai Thang Pham Toan Giap Tran Huu Vu Thi Kim Oanh Nguyen Thi Minh Hang |
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| Institution: | 1. Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
, Caugiay , Hanoi, Vietnam;2. Graduate University of Science and Technology, VAST
, Caugiay , Hanoi, Vietnam;3. huongdm@imbc.vast.vn lethanh@imbc.vast.vn;5. School of Chemical Engineering, Hanoi University of Science and Technology
, Ha Ba Trung , Hanoi, Vietnam;6. Institute of Forensic Sciences, Ministry of Public Security
, Thanh Xuan , Hanoi, Vietnam |
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| Abstract: | AbstractTwo new prenylated flavonoids, 4´-methyl-8-prenyltaxifolin (1) and 6,8-diprenyl-4´-methyl-naringenin (2) and a new geranylated stilbene, 4′-deprenyl-4-methoxymappain (3) together with eight known flavonoids (4–11) were isolated from the fruits of Macaranga balansae Gagnep. Their chemical structures were determined by means of spectroscopic methods including 1D, 2D NMR, and MS data. Compound 2 showed the highest cytotoxic activity against PanC1, A549, KB and LU-1 cell lines with IC50 values range from 7.89 to 22.81?µM. |
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| Keywords: | Macaranga balansae Euphorbiaceae prenylated flavonoid stilbene cytotoxic activity |
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