New citrinin derivatives from the deep-sea-derived fungus Cladosporium sp. SCSIO z015 |
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| Authors: | Muhammad Amin Xiao-Yong Zhang Xin-Ya Xu |
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| Affiliation: | 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong, China;2. University of the Chinese Academy of Sciences, Beijing, China |
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| Abstract: | AbstractDuring the course of our search for novel bioactive compounds from marine fungi, four new citrinin derivatives, cladosporins A–D (1–4) were isolated from a culture broth of the deep-sea-derived fungus Cladosporium sp. SCSIO z015. Their complete structural assignments were elucidated by the extensive spectroscopic investigation. The absolute configurations of 1–3 were established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compounds 1–4 showed weak toxicity towards brine shrine naupalii with LC50 values of 72.0, 81.7, 49.9 and 81.4?μM, respectively. And 4 also showed significant antioxidant activity against ɑ,α-diphenyl-picrylhydrazyl (DPPH) radicals with an IC50 value of 16.4?μM. |
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| Keywords: | Deep-sea-derived fungus Cladosporium sp. SCSIO z015 citrinin derivative toxicity antioxidant |
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