A immunosuppressive triterpenoid saponin from the stems of Epigynum griffithianum |
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| Authors: | Qun Wang Wen-Yi Li Yu-Dan Wang |
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| Affiliation: | 1. Department of Hepatopancreatobiliary Surgery, Hu bei Cancer Hospital, Wuhan, People’s Republic of China;2. swander@126.com;4. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, People’s Republic of China |
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| Abstract: | AbstractChemical investigation of the stems of Epigunum griffithianum led to the isolation and identification of a new triterpenoid saponin (1) and two known compounds (epigynosides A (2) and B (3)). These structures were elucidated by means of spectroscopic analysis (1D and 2D NMR, MS, UV, IR) as well as comparison with the reported data. Compound 1 was evaluated in vitro for the immunosuppressive activities on proliferation of mice splenocyte and displayed significant immunosuppressive activities compared to the positive control (dexamethasone) with the concentration at 25?μM. | |
| Keywords: | Epigunum griffithianum triterpenoid saponin immunosuppressive activity |
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