Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds |
| |
| Authors: | Yong-Xiang Wu You-Jeong Kim Tae-Hyung Kwon Chin-Ping Tan Kun-Ho Son |
| |
| Affiliation: | 1. College of Life and Environment Science, Huangshan University, Huangshan, PR China;2. Department of Food Science and Biotechnology, Andong National University, Andong, Korea;3. Chuncheon Bioindustry Foundation, Chuncheon, Korea;4. Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Malaysia;5. Department of Food and Nutrition, Andong National University, Andong, Korea |
| |
| Abstract: | AbstractMulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB. |
| |
| Keywords: | Mulberry root bark anti-inflammatory Diels-Alder type adducts albanol B |
|
|
