Two new anthraquinone derivatives and one new triarylbenzophenone analog from Selaginella tamariscina |
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| Authors: | Rui Liu Hui Zou Zhen-Xing Zou Fei Cheng Xia Yu Ping-Sheng Xu |
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| Affiliation: | 1. Xiangya Hospital of Central South University, Changsha, China;2. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China;3. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China;4. School of Medicine, Hunan Normal University, Changsha, China;5. Xiangya Hospital of Central South University, Changsha, China;6. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China |
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| Abstract: | AbstractTwo new anthraquinone derivatives, selaginones A (1) and B (2), and one new triarylbenzophenone analog, selagibenzophenone B (3), were isolated from Selaginella tamariscina (Beauv.) Spring. Their structures were established by 1D-, 2D-NMR and HR-ESI-MS data. Compounds 1 and 2 represent the uncommon examples of aryl substituted anthraquinone derivatives. Especially, compound 2 is a unique anthranone with exceptional structural feature, in which a p-hydroxyphenyl moiety is attached to the C-10 position. Compound 3 is the second naturally occurring triarylbenzophenone and showed moderate activity against SMCC-7721 and MHCC97-H cell lines with IC50 values of 39.8, 51.5 μM respectively. |
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| Keywords: | Selaginella tamariscina anthraquinone anthranone selaginone A selaginone B selagibenzophenone B hepatocellular carcinoma |
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