Three new ɑ-pyrone derivatives induced by chemical epigenetic manipulation of Penicillium herquei,an endophytic fungus isolated from Cordyceps sinensis |
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| Authors: | Da-Le Guo Ling Qiu Dan Feng Xin He Xiao-Hua Li Zhi-Xing Cao |
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| Institution: | The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P R China |
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| Abstract: | AbstractChemical epigenetic manipulation was applied to explore secondary metabolite of an endophytic fungus Penicillium herquei, which was obtained from the fruiting body of Cordyceps sinensis, and three previously undescribed polyketides with pyran-2-one scaffold were isolated from its fermentation broth containing 10?mg/L 5-aza-2-deoxycytidine (a frequently-used DNA methyltransferase inhibitor). The structures of these new compounds were identified by extensive spectroscopic analyses, and their absolute configurations were elucidated by quantum chemical ECD calculations. |
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| Keywords: | Penicillium herquei Cordyceps sinensis chemical epigenetic manipulation 2-Pyrone ECD calculation cytotoxicity |
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