Stereoselective total synthesis of Patulolide C |
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| Authors: | Bommareddy Pratapareddy Reddymasu Sreenivasulu Mandava Venkata Basaveswara Rao |
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| Affiliation: | 1. Department of Chemistry, Krishna University, Machilipatnam , Andhra Pradesh , India;2. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada , Andhra Pradesh , India |
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| Abstract: | AbstractStereoselective total synthesis of Patulolide C has been accomplished from easily available and inexpensive (S)-chiral epoxide. The key steps involved in the concise synthesis of Patulolide C utilizes ring opening of chiral epoxide, cleavage of 1,2-diol, deprotection of benzyl ether of hydroxyl acid and Yamaguchi macrolactonisation dilution conditions as key steps. The advantage of this method include inexpensive starting material, mild reaction conditions and high purity of products. |
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| Keywords: | (S)-chiral epoxide ring opening of chiral epoxide 1,2-diol cleavage stereoselective total synthesis Patulolide C |
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