Protective effect of Epicatechin on APAP-induced acute liver injury of mice through anti-inflammation and apoptosis inhibition |
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| Authors: | Hao Wu Yanni Xie Yali Xu Zehua Hu Xing Wan Hancheng Huang |
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| Institution: | 1. College of Medicine, Hubei University for Nationalities, Enshi, China;2. College of Life Sciences, Wuhan University, Wuhan, China;3. Renmin Hospital of Three Gorges University, Yichang, China;4. The First People’s Hospital of Yichang, Yichang, China |
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| Abstract: | AbstractEpicatechin (EC) is the most effective compound in Euonymus alatus (Thunb.)Sieb, and possesses a series of benefits, including anti-inflammatory, antioxidant, antiobesity and anticancer effects. In this study, we investigated the protective effects of EC in Acetaminophen(N-acetyl-p-aminophenol, APAP)-induced acute liver injury in C57BL/6J mice and explored the possible mechanisms involved in these effects. | |
| Keywords: | EC APAP anti-inflammation apoptosis acute liver injury |
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