Antifungal,anti-inflamatory and neuritogenic activity of newly-isolated compounds from Disporopsis aspersa |
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| Authors: | Fang-Li Gang Feng Zhu Chao-Fu Yang Xiao-Ting Li Hua Yang Ming-Xia Sun |
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| Institution: | 1. College of Chemistry &2. Pharmacy, Shaanxi Key Laboratory of Natural Products &3. Chemical Biology, Northwest A&4. F University, Yangling, P. R. China;5. School of Chemistry &6. Chemical Engineering, Yani’an University, Yani’an, P. R. China |
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| Abstract: | AbstractA new ester (1) and a terpenoid (2) were isolated from the dried whole plant of Disporopsis aspersa (HUA) ENGL. ex DIELS for the first time and their structures were elucidated, as well as their biological activities are described. The two compounds all showed good antifungal activities, especially furanone (2) exhibited better antifungal activity against Pseudoperonospora cubensis and Phytophthora infestans with EC50 value of 22.82, 18.90?μg/mL, respectively. Compound 1 exhibited a significant promotion on the neurite outgrowth in NGF-induced PC-12 cells, and moderate inhibition on the NO production induced by lipopolysaccharide (LPS) in BV-2 microglial cells. |
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| Keywords: | Disporopsis aspersa naphthylacetate ester antifungal activity neuritogenic activity anti-inflammatory activity |
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