Triterpene glycosides from the Vietnamese sea cucumber Holothuria edulis |
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Authors: | Le Hoang Vien Le Thi Hanh Tran Thi Hong Thanh Nguyen Van Nam Nguyen Hoai |
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Institution: | 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;2. Graduate University of Science and Technology, VAST, Hanoi, Vietnam |
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Abstract: | AbstractFrom the MeOH extract of the Vietnamese sea cucumber Holothuria edulis, eight triterpene glycosides (1–8), including one new compound namely holothurin A5 (1), were isolated by using various chromatographic separations. Their structures were established by spectroscopic experiments including 1D, 2D NMR and HR-ESI-MS. Holothurin A5 (1) has a hydroperoxy group at C-25. To the best of our knowledge, this is the first report of this group in triterpene saponins obtained from sea cucumbers to date. In addition, the in vitro cytotoxicity against five human cancer cell lines (HepG2, KB, LNCaP, MCF7 and SK-Mel2) of all isolated compounds was also evaluated using SRB assays. |
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Keywords: | Holothuria edulis holothuriidae triterpene glycoside cytotoxicity |
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