A new phenanthropyran and a new biphenanthrene from the rhizomes of Dioscorea septemloba and their antioxidant activities |
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Authors: | Tao He Yi Liu Rui-Feng Xiong Xiao-Yu Li |
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Institution: | 1. School of chemical engineering, Institute of pharmaceutical engineering technology and application, Analytical and testing center, Key laboratory of green chemistry of Sichuan institutes of higher education, Sichuan university of science &2. engineering, Zigong, People’s Republic of China |
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Abstract: | AbstractA new phenanthropyran, dioscorone B (1), and a new phenanthrene (2), together with seven known compounds (3–9), were isolated from the 75% ethanol extract of Dioscorea septemloba rhizomes. The chemical structures of these compounds were elucidated by comprehensive spectroscopic methods including NMR, HRESIMS, IR, and UV spectra. Compounds 1–5 were first isolated from genus Dioscorea. The proton and carbon chemical shifts of compounds 1–9 were unambiguously assigned based on the 1D-NMR and 2D-NMR data. Compounds 1–5 and 8–9 were first tested for their antioxidant activities. Compounds 1 and 2 showed excellent activities with IC50 values of 0.07?±?0.10?μM and 0.13?±?0.09?μM, respectively. |
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Keywords: | Dioscorea septemloba antioxidant activities phenanthrene derivative |
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