Antioxidant coumarin and pyrone derivatives from the insect-associated fungus Aspergillus Versicolor |
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| Authors: | Tian-Xiao Li Dan-Dan Meng Ying Wang Jin-Lu An Jia-Feng Bai Xue-Wei Jia |
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| Affiliation: | 1. College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou, Henan, China;2. The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;3. Technical Center of China, Tobacco Guangxi Industrial Co. Ltd, Nanning, Guanxi, China |
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| Abstract: | AbstractTwo new compounds, versicolones A and B (1 and 2), and three known pyrone derivatives (3?5) were isolated from the insect-associated fungus Aspergillus versicolor. Their structures were elucidated through a combination of HRESIMS and NMR spectroscopic analysis. Versicolone A (1) was revealed as a coumarin derivative with the rare 5-alkyl side chain substitution. Compound 5 exhibited significant antioxidant activity with EC50 value of 8.0?μM in the ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) assay, which was more than 2-fold potency of the positive control trolox. |
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| Keywords: | Insect-associated fungus Aspergillus versicolor coumarin antioxidant activity |
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