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New 2-(2-phenylethyl)chromone derivatives from agarwood and their inhibitory effects on tumor cells
Authors:Yang-Yang Liu  De-Li Chen  Zhang-Xin Yu  Wang Can-Hong  Jian Feng  Yu Meng
Institution:1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education &2. National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China;3. Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine &4. Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou, P. R. China;5. Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine &
Abstract:Abstract

Two new chromone derivatives, 7-hydroxy-2-2-(3'-methoxy-4'-hydroxyphenyl)-ethyl]chromone (1), and 6,7-dimethoxy-2-2-(3'-hydroxyphenyl)-ethyl]chromone (2) were isolated from the EtOH extract of agarwood of Aquilaria sinensis, together with eleven known analogues. Their structures were established by detailed HR-ESIMS, 1D and 2D NMR spectroscopic analysis, as well as comparison with the literature data. Selected the isolates (1, 2, 4–8, 10, 11) were tested for their antitumor activities against SMMC-7721, MGC-803 and OV-90 cell lines using the MTT method with cisplatin and paclitaxel as the positive control. All the tested compounds showed weak cytotoxic activities with IC50 values ranged from 18.82 to 37.95 µg/ml.
Keywords:Aquilaria sinensis  agarwood  2-(2-phenylethyl)chromone derivatives  Whole-tree Agarwood-inducing Technique
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