A new indole alkaloid with anti-inflammatory from the branches of Nauclea officinalis |
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| Authors: | Le-Ling Song Yan-Ling Mu Hao-Chao Zhang Gui-Ying Wu |
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| Affiliation: | 1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, 250200, China;2. Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062, China;3. Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062, China;4. Key Laboratory for Biotech-Drugs Ministry of Health, Jinan, Shandong, 250062, China;5. Key Laboratory for Rare &6. Uncommon Diseases of Shandong Province, Jinan, Shandong, 250062, China |
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| Abstract: | Abstract A new indole alkaloid, 17-oxo-19-(Z)-naucline, and six known alkaloids 2–7 were isolated from the branches of Nauclea officinalis. The structure of the new compound 1 was characterised mainly by analysing its physical data including IR, 1?D, 2?D NMR, and HR-ESI-MS. Other compounds were identified by comparisons their data with those reported in the literature. Compound1, 4, 5, 6, 7 showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitric oxide in RAW264.7 cell, while all compounds exhibited weak cytotoxicity against human tumour cell lines (LOVO, A549 and HepG2). |
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| Keywords: | Nauclea officinalis indole alkaloid anti-inflammatory activity cytotoxic activity |
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