Markhasphingolipid A,new phytosphingolipid from the leaves of Markhamia stipulata var. canaense V.S. Dang |
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| Authors: | Trong Nghia Ngo Nu Dan Phuong Nguyen Ngoc Thien Ly Nguyen Nguyen Kim Tuyen Pham Nhat Minh Phan Trong Dat Bui |
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| Institution: | 1. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam;2. Kien Giang University, Kien Giang Province, Vietnam;3. Sai Gon University, Ho Chi Minh City, Vietnam;4. Tran Phu High School, Binh Phuoc Province, Vietnam;5. Tan Hiep High School, Kien Giang Province, Vietnam;6. Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam |
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| Abstract: | AbstractFrom the leaves of Markhamia stipulata var. canaense V.S. Dang, one new phytosphingolipid, named markhasphingolipid A (6) together with five known compounds, 4’,7-O-dimethylapigenin (1), narigenin (2), tectoquinone (3), mollic acid (4), 1-hexadecanoyl-sn-glycerol (5) were classified by various chromatographic methods. Their structures were designated by IR, UV, HR-ESI-MS, HR-ESI-MS/MS and NMR experiments. All compounds were recognized for the first time from this species. The cytotoxicity of all n-hexane fractions and isolated compounds (5 & 6) against three human cancer cell lines (HeLa, HepG2, and MCF-7) were evaluated by SRB assay. All n-hexane fractions expressed cytotoxic effect on three tested cancer cell lines (at the concentration of 100?μg/mL, percent of cytotoxicity ranged from 55.81% to 95.83%) as well as compound 5 (IC50 ranged from 48.51 to 63.30?μM) whereas fraction H.I and compound 6 did not show activity. | |
| Keywords: | Markhamia stipulata Bignoniaceae Markhasphingolipid A cytotoxic activity |
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