Green approaches for the synthesis of nucleotides,their conjugates and analogues |
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Authors: | Lucie Appy Anaïs Depaix Xavier Bantreil Frédéric Lamaty Suzanne Peyrottes |
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Institution: | 1. Nucleosides &2. Phosphorylated Effectors, IBMM, Univ Montpellier CNRS, ENSCM, Montpellier, France;3. Green Chemistry and Enabling Technologies, IBMM, Univ Montpellier CNRS, ENSCM, Montpellier, France |
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Abstract: | AbstractWe have developed original one-pot and protecting group-free approaches, which are also user-friendly and reliable, to synthesize nucleotides and derivatives starting from nucleoside 5’-monophosphates. Both methods present convenient set-up, i.e., non-dry solvents and reagents, substrates in their sodium or acid form, and commercially available and cheap phosphorus reagents as sodium and potassium salts. |
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Keywords: | Organophosphorus chemistry nucleotides dinucleotides water chemistry mechanochemistry |
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