Chemical profile and biological activities of Peltigera horizontalis (Hudson) Baumg. thallus and apothecia extracts |
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| Authors: | Gordana Stojanović Ivana Zrnzević Ivana Zlatanović Miroslava Stanković Vesna Stankov Jovanović Violeta Mitić |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science and Mathematics, University of Ni?, Ni?, Serbia;2. gocast@pmf.ni.ac.rs;4. Department of Radiation Safety and Environmental Protection, Nuclear Facilities of Serbia, Vin?a, Serbia |
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| Abstract: | AbstractThe aim of this study was to determine, for the first time, the chemical composition of Peltigera horizontalis thallus and apothecia extracts (ether, ethyl acetate, dichloromethane and acetone) by HPLC-UV and GC-MS, and evaluate activity of genotoxic, anticholinesterase, antioxidant and antibacterial potential of acetone extracts. Major constituents of thallus extracts were gyrophoric acid, and methyl gyrophorate while dominant component of apothecia extracts was tenuiorin. The predominant volatile compounds in extracts were methyl orsellinate, dodecyl acrylate, orcinol and orcinol monomethyl ether. The thallus acetone extract at concentration of 2.0 µg mL?1 gave the greatest decrease in the micronuclei frequency (22.4%) of all tested extracts. Apothecia extract showed stronger antioxidant activity as compared to thallus extract. Tested extracts at concentration of 10?mg mL?1 exhibited inhibitory effect (16.5% for thallus and 12.8% for apothecia) on pooled human serum cholinesterase. P. horizontalis acetone extracts had no activity against the tested five bacteria strains. |
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| Keywords: | Peltigera horizontalis (Hudson) Baumg. antioxidant activity antibacterial activity genotoxicity cholinesterase inhibition HPLC-UV profile GC-MS profile |
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