A new 22,26-seco physalin steroid from Physalis angulata |
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| Authors: | Jutatip Boonsombat Pornsuda Chawengrum Chulabhorn Mahidol Prasat Kittakoop Somsak Ruchirawat |
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| Institution: | 1. Laboratory of Natural Products, Chulabhorn Research Institute, Bangkok, Thailand;2. Chulabhorn Graduate Institute, Chemical Biology Program, Chulabhorn Royal Academy, Bangkok, Thailand;3. Chulabhorn Graduate Institute, Chemical Biology Program, Chulabhorn Royal Academy, Bangkok, Thailand;4. Center of Excellence on Environmental Health and Toxicology (EHT), PERDO, The Ministry of Education, Thailand |
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| Abstract: | AbstractA new 22,26-seco physalin, physalin XI (1) together with 5 known compounds, were isolated from the dichloromethane extract of Physalis angulata L. The structure of isolated compounds was elucidated by spectroscopic analysis. The effects of isolated compounds on in vitro cytotoxicity were investigated. Compound 1 was assessed for its cytotoxicity against cancer cell lines (HepG2, HeLa, HuCCA-1, T47-D and A-549) and a normal cell line (MRC-5), and the result showed that it has no activity. Compounds 2 and 4 are highly toxic to H69AR and MDA-MB-23 cell lines. This property appears to be related to the presence of their conjugated double bond or epoxy groups and is a more reliable indication of toxicity than substitution on C(5)–C(6). |
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| Keywords: | Physalis angulata Solanaceae physalin steroid cytotoxicity |
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