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Auroglaucin-related neuroprotective compounds from Vietnamese marine sediment-derived fungus Aspergillus niveoglaucus |
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| Authors: | Anton N Yurchenko Olga F Smetanina Elena V Ivanets Trinh Thi Hoai Phan Ngoc Thi Duy Ngo Olesya I Zhuravleva |
| Institution: | 1. G.B. Elyakov Pacific Institute of bioorganic chemistry, Vladivostok, Russia;2. yurchant@ya.ru;4. Department of marine biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang, Vietnam;5. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam;6. Laboratory of Biologically Active Compounds, Far Eastern Federal University, Vladivostok, Russia |
| Abstract: | AbstractTwo new auroglaucin-derived compounds, niveoglaucins A (1) and B (2), together with four known related compounds were isolated from extract of the marine sediment-derived strain of Aspergillus niveoglaucus. The structures of these compounds were determined by 1D and 2D NMR spectroscopy and high resolution MS. The plausible biosynthetic pathway was proposed for new compounds 1 and 2. The neuroprotective activity in 6-OHDA-induced Parkinson’s disease cell model was shown for niveoglaucin A (1). |
| Keywords: | Aspergillus niveoglaucus Eurotium niveoglaucum marine-derived fungus secondary metabolites neuroprotective activity Parkinson’s disease |