Ex vivo evaluation of the effects of a white grape juice extract on lymphocytic mitochondrial functions |
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Authors: | Giuseppa Visalli Nadia Ferlazzo Alessio Facciolà Isa Picerno Angela Di Pietro |
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Affiliation: | 1. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy;2. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy |
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Abstract: | AbstractThe physio-pathological role of mitochondria in aging and age-related diseases has stimulated the search for compounds able to promote mitochondrial functionality. Our study was designed to evaluate the effect of a white grape juice extract (WGJe) on mitochondrial activity, in an ex vivo experimental model consisting of activated lymphocytes obtained from a younger age group and an older age group of subjects. WGJe steadily decreased the lymphocytic mitochondrial mass in the older subjects, without a relevant effect in their younger counterpart, and significantly enhanced Δψm in both groups investigated. Finally, WGJe reduced the endogenous mitochondrial production of H2O2 in all subjects. The results support the potential use of WGJe to improve mitochondrial functionality, thus maintaining human health and slowing down aging. |
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Keywords: | Grape juice mitochondrial function lymphocytes aging resveratrol |
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