Neocucurbitacin D,a novel lactone-type norcucurbitacin as xanthine oxidase inhibitor from Herpetospermum pedunculosum |
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| Authors: | He-Zhong Jiang Sha Hu Ren-Xiang Tan Rui Tan |
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| Institution: | 1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, P.R. China;2. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P.R. China;3. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P.R. China |
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| Abstract: | AbstractA novel lactone-type norcucurbitacin, designated as neocucurbitacin D (1), together with five known cucurbitane triterpenes were isolated from traditional Tibetan medicine “Se Ji Mei Duo”, which is the seed of Herpetospermum pedunculosum (Ser.) C.B. Clarke. The structure of neocucurbitacin D was elucidated by spectroscopic analysis, including 2D NMR and X-ray techniques. Compounds 1–6 were screened for their xanthine oxidase (XOD) inhibitory activity. Compound 1, 2 and 4 exhibited significant XOD inhibition with IC50 values ranging from 10.16 to 18.41?μM. The absolute stereochemistry and XOD inhibitiory activity of lactone-type norcucurbitacins was reported firstly. |
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| Keywords: | Herpetospermum pedunculosum Norcucurbitacin Cucurbitane triterpenes Xanthine oxidase inhibitor |
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