Hypepontine,a new quaternary alkaloid with antimicrobial properties |
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| Authors: | Tsvetelina Doncheva Nadezhda Kostova Violeta Valcheva Radostina Toshkovska Vassil Vutov Stefan Philipov |
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| Institution: | 1. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria;2. tsvety@orgchm.bas.bg;4. Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria;5. In Vitro Laboratory for Evaluation of Biological Activity and Toxicity, Sofia Tech Park, Sofia, Bulgaria;6. National Museum of Natural History, Bulgarian Academy of Sciences, Sofia, Bulgaria |
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| Abstract: | AbstractNew isoquinoline alkaloid hypepontine (1) together with a five known compounds, were identified in Hypecoum ponticum Velen, the partial synonym of Hypecoum procumbens L. The structure of the new substance was elucidated based on spectroscopic evidence. The tertiary and quaternary alkaloid mixtures as well as the isolated alkaloids were evaluated for their antibacterial and antifungal activity. The result revealed that the crude alkaloid mixture containing quaternary isoquinoline alkaloids showed potent antifungal and antibacterial activity. |
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| Keywords: | Hypecoum ponticum Hypecoum procumbens alkaloids hypepontine antimicrobial activity |
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