Isolation of a new natural kingiside aglucone derivative and other anti-inflammatory constituents from Syringa reticulata |
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| Authors: | Chunshi Jin Mei Jin Ren Li Shengbao Diao Jinfeng Sun Ying Jie Ma |
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| Institution: | 1. Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, P. R. China;2. Department of Pharmacy, Yanbian University Hospital, Yanji, P. R. China;3. The Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, , Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |
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| Abstract: | AbstractA new secoiridoid, (1R,5S,8S,9R)-1-methyl-kingiside aglucone (1), along with nine known compounds (2–10), were isolated from the ethanol extract of the stem bark of Syringa reticulata (Bl.) Hara. The structure of compound 1 was elucidated using HR-ESI-MS, 1D and 2D NMR spectroscopy. Compounds 1–10 were evaluated for their inhibitory activity against NO, TNF-α and IL-6 production. Compounds 1, 3, 5 and 7–10 significantly inhibited the levels of NO, TNF-α and IL-6 in LPS-induced RAW264.7 cells from concentrations of 3 to 30?μM. |
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| Keywords: | Syringa reticulate secoiridoid kingiside aglucone derivative NO TNF-α IL-6 |
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