Perisomalien A,a new cytotoxic scalarane sesterterpene from the fruits of Periploca somaliensis |
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| Authors: | Khadijah A Jabal Hossam M Abdallah Gamal A Mohamed Ibrahim A Shehata Mohammad Y Alfaifi Serag Eldin I Elbehairi |
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| Institution: | 1. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia;3. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt;4. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt;5. Faculty of Science, Biology Department, King Khalid University, Abha, Saudi Arabia;6. Cell Culture Lab, Egyptian Organization for Biological Products and Vaccines (VACSERA Holding Company), Agouza, Giza, Egypt |
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| Abstract: | AbstractThe CHCl3 fraction of MeOH extract of Periploca somaliensis (family Asclepiadaceae) fruits afforded a new scalarane sesterterpene, namely perisomalien A (1), along with lupeol acetate (2), β-amyrin (3), cycloart-23Z-ene-3β,25-diol (4), and β-sitosterol-3-O-β-D-glucopyranoside (5). Their chemical structures were established by various spectroscopic analyses, in addition to comparison with the formerly reported data. Moreover, the cytotoxic activity of these metabolites was assessed towards MCF-7, HepG2, and HCT-116 tumour cell lines using sulforhodamine B (SRB) assay. Compound 4 showed the most potent cytotoxic profile with IC50 9.0?µM towards MCF-7, compared to doxorubicin (IC50 0.18?µM). Also, 1 and 4 possessed the most potent effect towards HepG2 with IC50s 26.7 and 25.9?μM, respectively. In addition, all tested compounds showed cytotoxic effects with IC50 values ranging from 19.9 to 39.3?µM against HCT-116. |
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| Keywords: | Periploca somaliensis Asclepiadaceae scalarane sesterterpene perisomalien A cytotoxic |
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