Rapid microwave promoted Sonogashira coupling reactions on solid phase |
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| Authors: | Erdélyi Máté Gogoll Adolf |
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| Affiliation: | Department of Organic Chemistry, Uppsala University, Box 599, 751 24 Uppsala, Sweden. |
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| Abstract: | A microwave-enhanced, rapid, and efficient solid-phase version of the Sonogashira reaction is presented. It has been applied to the coupling of aryl iodides and bromides with various acetylene derivatives giving excellent yields in 15-25 min. The scopes of homogeneous, solventless, and solid-phase conditions for Sonogashira coupling of aryl halides are compared. |
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