| 新颖桥联核苷化合物的合成 |
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| 引用本文： | 徐效华,迟国臣,卢建华,姚广民,李艳明,陈茹玉.新颖桥联核苷化合物的合成[J].高等学校化学学报,2001,22(Z1):120-123. |
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| 作者姓名： | 徐效华 迟国臣 卢建华 姚广民 李艳明 陈茹玉 |
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| 作者单位： | 南开大学元素有机化学研究所, 天津 300071 |
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| 摘 要： | 报道了以鸟苷和尿苷为起始原料通过碱基端基连接而成两种新型桥联双聚体核苷的合成方法.通过1,2,4-三氮唑与POCl3在缚酸剂Et3N催化下分别与鸟苷碱基6-位和尿苷碱基4-位内酰胺羰基反应生成相应的1,2,4-三氮唑基核苷2和6,然后分别使其C-6和C-4位活化,进一步与二烷基胺反应,最后脱保护, 就很方便得到两种新型桥联双聚体核苷4和8.
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| 关 键 词： | 桥联双聚体核苷 合成 结构表征 |
| 文章编号： | 0251-0790(2001)10Z-120-04 |
| 收稿时间： | 2001-07-27 |
| 修稿时间： | 2001年7月27日 |
Synthesis of Novel Bridged Dinucleosides |
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| XU XiaoHua,CHI Guo-Chen,LU Jian-Hua,YAO Guang-Min,LI Yan-Ming,CHEN Ru-Yu.Synthesis of Novel Bridged Dinucleosides[J].Chemical Research In Chinese Universities,2001,22(Z1):120-123. |
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| Authors: | XU XiaoHua CHI Guo-Chen LU Jian-Hua YAO Guang-Min LI Yan-Ming CHEN Ru-Yu |
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| Institution: | Institute of Elemento-Organic Chemistry, Nankai University, TianJin 300071, China |
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| Abstract: | A methodology for the synthesis of novel bridged dinucleosides(4, 8) has been reported. The synthesis of target compounds was started from guanosine,uridine, the fully O-acyl-guanosine and uridine were treated with POCl3 in the presence of excessive 1, 2, 4-triazole to give the triazolide derivative (2, 6) which was treated with dialkylamine (0.5 equiv.) to afford the expected protected dimer(3a, 3b, 7a and 7b), after deprotected by MeOH/NH3 solution, the dimers (4a, 4b, 8a and 8b) were obtained, respectively. |
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| Keywords: | Novel bridged dinucleosides Synthesis Spectra analysis |
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