环境响应性多肽自组装研究进展

分子自组装广泛存在于自然界中,参与生物体的各项生命活动,从而确保生物体相关生理功能的实现和生化反应的有序进行.多肽自组装作为分子自组装的重要组成部分,其良好的生物相容性为构建具有重要应用价值的生物医用材料提供了新的思路.本文总结了多肽自组装过程中主要的驱动作用力;简述了多肽自组装形成的主要结构;详细介绍了自组装过程中环境变化,包括pH、温度、离子强度、特殊离子、氧化还原态以及光照等,对于环境响应性多肽自组装结构和性质的影响;并且阐述了多肽自组装生物材料的应用方向和前景,希望为该领域的进一步研究提供参考.

Self-assembly of environmental responsive peptide

As a widely existing phenomenon in nature, molecular self-assembly participates in most biological activities of organisms to achieve the relevant physiological function and biochemical reaction. Being an important part of molecular self-assembly, peptide self-assembly has extraordinary biological compatibility, which provides new insights on the design of important materials with biological and medical application. Herein we summarized the main driving force for peptide self-assembly and the main structures resulting from peptide self-assembly. Furthermore, the effects of environmental changes on peptide self-assembly were discussed in detail, which include pH, temperature, ionic strength, special ions, redox state and light. Finally, the application of peptide self-assembly in drug delivery, tissue engineering, biomineralization, and the development of antibacterial agents were demonstrated.