| 膦酰肽和膦酰酯肽的汇聚式合成 |
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| 引用本文： | 许家喜. 膦酰肽和膦酰酯肽的汇聚式合成[J]. 中国科学B辑, 2013, 0(8): 995-1004 |
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| 作者姓名： | 许家喜 |
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| 作者单位： | 北京化工大学理学院有机化学系;化工资源有效利用国家重点实验室,北京100029 |
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| 基金项目： | 国家自然科学基金（20972013）的资助本工作得到国家自然科学基金（20972013）的资助,特此致谢 |
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| 摘 要： | 本文首先介绍了膦酰肽的分类、结构特征以及膦酰肽的主要合成方法,然后详细介绍了类Mannich反应在合成氨基膦酸衍生物中的应用,并介绍了以类Mannich反应为关键步骤通过汇聚式的方法合成膦酰肽、膦酰酯肽、次膦酰肽、次膦酰酯肽、磺酰膦酰杂交肽的研究进展.汇聚式的合成方法具有原料简单、合成步骤少、原子经济性好等优点.
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| 关 键 词： | 膦酰肽 类Mannich反应 合成 多组分缩合 |
Convergent synthesis of phosphonopeptides |
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| XU JiaXi. Convergent synthesis of phosphonopeptides[J]. Science in China(Series B), 2013, 0(8): 995-1004 |
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| Authors: | XU JiaXi |
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| Affiliation: | XU JiaXi( State Key Laboratory of Chemical Resource Engineering; Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China) |
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| Abstract: | The classification, structural characteristics, and main synthetic methods of phosphonopeptides were described. The application of Mannich-type reaction in the synthesis of 1-aminoalkylphosphonic derivatives and the convergent synthesis of phosphonopeptides, depsiphosphonopeptides, phosphinopeptides, depsiphosphinopeptides, hybrid sulfonophosphinopeptides via the Mannich-type reaction as a key step were introduced in details. The convergent synthetic method shows some advantages, such as simple starting material, less reaction steps, high atomic economy and so on. |
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| Keywords: | phosphonopeptide Mannich-type reaction synthesis multiple component condensation |
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