| Synthesis of Novel Spin Labeled Daunomycin Derivatives |
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| 引用本文： | Shu Jia ZHANG*,Yan Guang WANG*,Ju Biao LI Department of Chemistry,Zhejiang University,Hangzhou 310027. Synthesis of Novel Spin Labeled Daunomycin Derivatives[J]. 中国化学快报, 2001, 0(6) |
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| 作者姓名： | Shu Jia ZHANG* Yan Guang WANG* Ju Biao LI Department of Chemistry Zhejiang University Hangzhou 310027 |
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| 作者单位： | Shu Jia ZHANG*，Yan Guang WANG*，Ju Biao LI Department of Chemistry，Zhejiang University，Hangzhou 310027 |
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| 摘 要： | The anthracycline antibiotics daunomycin 1 is clinically useful antineoplastic agents, with a broad spectrum of activity. However, it is hampered by a number of undesirable side effects, especially serious cardiotoxicity and this stimulated the search for new anthracyclines with improved pharmacological profiles1-3. In our group, nitroxy radicals were first introduced to daunomycin and two spin labeled daunomycin derivatives have been reported recently4. Now we reported other three new spin la…
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Synthesis of Novel Spin Labeled Daunomycin Derivatives |
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| Shu Jia ZHANG,Yan Guang WANG,Ju Biao LI. Synthesis of Novel Spin Labeled Daunomycin Derivatives[J]. Chinese Chemical Letters, 2001, 0(6) |
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| Authors: | Shu Jia ZHANG Yan Guang WANG Ju Biao LI |
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| Affiliation: | Shu Jia ZHANG*,Yan Guang WANG*,Ju Biao LI Department of Chemistry,Zhejiang University,Hangzhou 310027 |
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| Abstract: | Three spin labeled daunomycin derivatives 2-4 were synthesized and their biological activities were tested against mouse leukemia L1210 and human liver cancer BEL-7402 cells in vitro. |
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| Keywords: | Spin labeled daunomycin derivatives antitumor activity synthesis. |
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