Divergent synthesis of cytotoxic styryl lactones from D-xylose. The first total synthesis of (+)-crassalactone C |
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| Authors: | Popsavin Velimir Benedeković Goran Srećo Bojana Popsavin Mirjana Francuz Jovana Kojić Vesna Bogdanović Gordana |
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| Institution: | Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovi?a 3, 21000 Novi Sad, Serbia. popsavin@ih.ns.ac.yu |
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| Abstract: | A new divergent approach to (+)-goniofufurone (1) and 7-epi-(+)-goniofufurone (2), as well as the first total synthesis of crassalactone C (3), has been achieved starting from D-xylose. In a preliminary bioassay, all three natural products 1, 2, and 3 showed remarkable in vitro antiproliferative activities against K562, Raji, and HeLa neoplastic cell lines. |
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