Asymmetric synthesis of the core structure of leucosceptroids A-D |
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| Authors: | Xie Jun Ma Yuelong Horne David A |
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| Institution: | Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California 91010, USA. |
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| Abstract: | The asymmetric synthesis of the core structure of leucosceptroids A-D has been achieved. The key steps of the synthesis includes the formation of the cis-2,5-disubstituted THF ring by TPAP catalytic oxidative cyclization followed by a highly diastereoselective intramolecular Diels-Alder reaction to fashion the fused tricyclic hydrindane ring system. |
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