Rhodium(III)-catalyzed oxidative mono- and di-olefination of isonicotinamides |
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| Authors: | Wei Xiaohong Wang Feng Song Guoyong Du Zhengyin Li Xingwei |
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| Institution: | Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China. |
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| Abstract: | RhCp*Cl(2)](2) can catalyze the oxidative coupling of secondary isonicotinamides with activated olefins using Cu(OAc)(2) as an oxidant. The selectivity can be controlled by the solvent. In MeCN, the mono-olefination and two-fold oxidation reaction is the major pathway, while in THF this reaction gave mostly diolefination products. In both cases, the coupled products contain an exocyclic C=C bond. |
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