A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core |
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Authors: | Denton Ross M Scragg James T |
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Affiliation: | School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. ross.denton@nottingham.ac.uk |
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Abstract: | A synthesis of the core ring structure of the fargenin/fargenone family of natural products is presented. The general strategy is based upon biosynthetic speculation and exploits a cascade reaction, which transforms a spirocyclic dienone into the core ring system via a deprotonation-oxy-Michael-Wittig olefination sequence. This study represents the first synthesis work towards this family of natural products. |
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