Synthesis and biological evaluation of indoloquinolines and pyridocarbazoles: a new example of unexpected photoreduction accompanying photocyclization |
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Authors: | Aragon Pierre-Jean Yapi Ange-Désiré Pinguet Frédéric Chezal Jean-Michel Teulade Jean-Claude Blache Yves |
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Affiliation: | Laboratoire de Chimie Organique Pharmaceutique, EA 2414, Faculté de Pharmacie, Montpellier, France. |
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Abstract: | Indoloquinoline alkaloid cryptolepine and pyridocarbazole alkaloid ellipticine are of great interest because in vitro and in vivo studies revealed their good cytotoxic properties. In order to obtain some biologically active analogs of these compounds, we developed a synthesis based on the photocyclization of tertiary N-substituted enaminones derived from 1,3-cyclohexandione and 3 or 6-aminoquinoline. The angular cyclized compounds thus obtained were tested in vitro on K 562 cells and A 2780 doxorubicin sensitive and resistant cells. All compounds were less effective than doxorubicin in sensitive cells but their activity wasn't decreased by MDR resistance. |
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