| Effect of Enteral Nutrition Formula on Fat Absorption and Serum Free Fatty Acid Profiles in Rat with Short-Bowel Syndrome |
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| 引用本文： | 周建农 谭力 王学浩 鞠熀先. Effect of Enteral Nutrition Formula on Fat Absorption and Serum Free Fatty Acid Profiles in Rat with Short-Bowel Syndrome[J]. 中国化学, 2006, 24(10): 1368-1374. DOI: 10.1002/cjoc.200690255 |
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| 作者姓名： | 周建农 谭力 王学浩 鞠熀先 |
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| 作者单位： | The First Clinical Medical College Nanjing Medical University，Nanjing，Jiangsu 210029，China，Key Laboratory of Analytical Chemistry for Life Science(Ministry of Eduction of China)，Department of Chemistry，Nanjing University，Nanjing，Jiangsu 210093，China，The First Clinical Medical College，Nanjing Medical University，Nanjing，Jiangsu 210029，China，Key Laboratory of Analytical Chemistry for Life Science(Ministry of Eduction of China)，Department of Chemistry，Nanjing University，Nanjing，Jiangsu 210093，China |
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| 基金项目： | Project supported by the National Science Fundation for Distinguished Young Scholars(No.20325518)，Creative Research Groups(No.20521503)，the Key(No.20535010)，General Programs(No.20275017)from the National Natural Science Foundation of China. |
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| 摘 要： | The effects of enteral nutrition containing long chain triglycerides(LCT)and medium chain triglycerides(MCT)or L-arginine(Arg)on fat absorbability,serum free fatty acid profiles and intestinal morphology in rats withshort-bowel syndrome(SBS)were studied using gas chromatography.Twenty-eight Sprague-Dawley rats wererandomly assigned to 4 groups:sham operation fed with LCT as control;85% small bowel resection fed with LCT,MCT/LCT,and Arg/LCT,respectively.SBS rats showed a decrease of fat absorptivity.Enteral nutrition supple-mented with MCT could increase fat absorptivity.L-Arginine enhanced enteral nutrition was associated with theelevation of fat absorptivity,possibly due to its enterotrophic effect on remnant small bowel mucosa.LCT groupshowed a significant deficiency of total free fatty acid and the decreased essential fatty acid content,which was im-proved in other two SBS groups.
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| 关 键 词： | 血清脂肪酸 脂肪吸收率 气相色谱 短肠综合病症 肠道营养 |
| 收稿时间： | 2006-02-15 |
| 修稿时间： | 2006-02-152006-06-08 |
Effect of Enteral Nutrition Formula on Fat Absorption and Serum Free Fatty Acid Profiles in Rat with Short-Bowel Syndrome |
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| ZHOU Jian-Nong, TAN Li, WANG Xue-Hao, JU Huang-Xian . Effect of Enteral Nutrition Formula on Fat Absorption and Serum Free Fatty Acid Profiles in Rat with Short-Bowel Syndrome[J]. Chinese Journal of Chemistry, 2006, 24(10): 1368-1374. DOI: 10.1002/cjoc.200690255 |
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| Authors: | ZHOU Jian-Nong TAN Li WANG Xue-Hao JU Huang-Xian |
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| Affiliation: | Ministry of Eduction of China |
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| Abstract: | The effects of enteral nutrition containing long chain triglycerides(LCT)and medium chain triglycerides(MCT) or L-arginine(Arg)on fat absorbability,serum free fatty acid profiles and intestinal morphology in rats with short-bowel syndrome(SBS)were studied using gas chromatography.Twenty-eight Sprague-Dawley rats were randomly assigned to 4 groups:sham operation fed with LCT as control;85% small bowel resection fed with LCT, MCT/LCT,and Arg/LCT,respectively.SBS rats showed a decrease of fat absorptivity.Enteral nutrition supple- mented with MCT could increase fat absorptivity.L-Arginine enhanced enteral nutrition was associated with the elevation of fat absorptivity,possibly due to its enterotrophic effect on remnant small bowel mucosa.LCT group showed a significant deficiency of total free fatty acid and the decreased essential fatty acid content,which was im- proved in other two SBS groups. |
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| Keywords: | serum fatty acid profile fat absorptivity gas chromatography short bowel syndrome enteral nutrition formula rat |
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