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Convenient grafting through approach for the preparation of stealth polymeric blood pool magnetic resonance imaging contrast agents |
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| Authors: | Mathurin Grogna Rudi Cloots André Luxen Christine Jérôme Catherine Passirani Nolwenn Lautram Jean‐F. Desreux Christophe Detrembleur |
| Affiliation: | 1. Center for Education and Research on Macromolecules, University of Liège, B6 Sart‐Tilman, Liège B‐4000, Belgium;2. Laboratoire de chimie inorganique structurale, University of Liège, B6 Sart Tilman, Liège B‐4000, Belgium;3. Cyclotron Research Centre, University of Liège, B6 Sart Tilman, Liège B‐4000, Belgium;4. INSERM U 646, 10 Rue A Boquel, Angers 49000, France;5. Coordination and Radiochemistry, University of Liège, B6 Sart Tilman, Liège B‐4000, Belgium |
| Abstract: | New hydrosoluble magnetic resonance imaging (MRI) macrocontrast agents are synthesized by reversible addition fragmentation chain transfer (RAFT) copolymerization of poly(ethylene oxide) methyl ether acrylate (PEOMA) with an acrylamide bearing a ligand for gadolinium, followed by the complexation of Gd3+. This convenient and simple grafting through approach leads to macrocontrast agents with a high relaxivity at high frequency that is imparted by the restricted tumbling of the Gd3+ complex caused by its attachment to the polymer backbone. Importantly a very low protein adsorption is also evidenced by the hemolytic CH50 test. It is the result of the poly(ethylene oxide) (PEO) brush that efficiently hides the gadolinium complex and renders it stealth to the proteins of the immune system. Improved contrast and long blood circulating properties are thus expected for these macrocontrast agents. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011 |
| Keywords: | biological applications of polymers functionalization of polymers gadolinium complex grafting through MRI reversible addition‐fragmentation chain transfer (RAFT) |