Single-molecule detection of biomolecules by surface-enhanced coherent anti-Stokes Raman scattering |
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Authors: | Koo Tae-Woong Chan Selena Berlin Andrew A |
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Affiliation: | Precision Biology, Intel Research/CTM, Intel Corporation, Santa Clara, California 95054, USA. tae-woong.t.koo@intel.com |
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Abstract: | We report on the applicability of combining surface-enhanced Raman scattering (SERS) with coherent anti-Stokes Raman scattering for high-sensitivity detection of biological molecules. We found that this combination of techniques provides more than 3 orders of signal enhancement compared with SERS and permits monitoring of biological molecules such as deoxyguanosine monophosphate (dGMP) and deoxyadenosine monophosphate at the single-molecule level. This combined technique also improved detection sensitivity for angiotensin peptide. As this is believed to be the first report of detection of dGMP at the single-molecule level, we suggest that this approach can serve as a new tool for biological studies. |
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