| 5-(呋喃-2-基)-3-苯基异噁唑的合成及其对硫酸盐还原菌的抑制活性 |
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| 引用本文： | 陈刚,邓强,汤颖,陈世军. 5-(呋喃-2-基)-3-苯基异噁唑的合成及其对硫酸盐还原菌的抑制活性[J]. 合成化学, 2010, 18(1) |
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| 作者姓名： | 陈刚 邓强 汤颖 陈世军 |
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| 作者单位： | 西安石油大学,化学化工学院,陕西,西安,710065;西安石油大学,化学化工学院,陕西,西安,710065;西安石油大学,化学化工学院,陕西,西安,710065;西安石油大学,化学化工学院,陕西,西安,710065 |
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| 基金项目： | 陕西省自然科学基础研究计划资助项目,陕西省教育厅专项科研计划资助项目 |
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| 摘 要： | 苯乙酮和呋喃甲醛在氢氧化钠作用下制得3-(呋喃基-2)-1-苯基-丙烯酮(1);1与羟氨经串联反应(缩合、加成和氧化芳构化)合成了5-(呋喃-2)-3-苯基异噁唑(3),总收率41.2%,其结构经NMR和MS表征。抑菌活性测试结果表明,3用作油田杀菌剂对硫酸盐还原菌有一定的抑制作用。
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| 关 键 词： | 异噁唑 苯乙酮 呋喃甲醛 油田杀菌剂 抑菌活性 合成 |
Synthesis of 5-(Furan-2-yl)-3-phenyl-isoxazole and Its Inhibition against Sulfate Reducing Bacteria |
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| CHEN Gang,DENG Qiang,TANG Ying,CHEN Shi-jun. Synthesis of 5-(Furan-2-yl)-3-phenyl-isoxazole and Its Inhibition against Sulfate Reducing Bacteria[J]. Chinese Journal of Synthetic Chemistry, 2010, 18(1) |
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| Authors: | CHEN Gang DENG Qiang TANG Ying CHEN Shi-jun |
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| Abstract: | 3-(Furan-2-yl)-1-phenyl-propenone(1) was prepared by the reaction of acetophenone with furfural in the presence of NaOH.5-(Furan-2-yl)-3-phenyl-isoxazole(3) in total yield of 41.2% was synthesized by a tandem reaction(condensation,addition and oxidation aromatization) of 1 with hydroxylamine.The structure was characterized by NMR and MS.The inhibition activity test result showed that 3 exhibited inhibition against sulfate reducing bacteria using an oilfield bactericide. |
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| Keywords: | isoxazole acetophenone furfural oilfield bactericide tandem reaction inhibition synthesis |
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