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Chemical transformations of N-morpholinylacetic acid hydrazide and steric structure of its derivatives |
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| Authors: | O A Nurkenov S D Fazylov Zh B Satpaeva I V Kulakov K M Turdybekov D M Turdybekov S A Talipov B T Ibragimov |
| Institution: | 1720. Institute of Organic Synthesis and Coal Chemistry of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, Kazakhstan 2720. International Research and Production Holding “Phytochemistry,”, ul. Gazalieva 4, Karaganda, 100008, Kazakhstan 3720. Multi-Profile Humanitarian-Technical University, pr. Bukhar Zhyrau 12, Karaganda, 100000, Kazakhstan 4720. Sadykov Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent, Uzbekistan |
| Abstract: | The reaction of N-morpholinylacetic acid hydrazide with various isothiocyanates and potassium thiocyanate resulted in the corresponding potentially biologically active thiosemicarbazide derivatives. Potassium N′-(2-morpholin-4-ylacetyl)hydrazinocarbothioate was synthesized and involved into heterocyclization in acidic environment to yield cyclic 5-(morpholinomethyl)-1,3,4-thiadiazole-2-thione. The structure of the synthesized compounds was established by IR, 1H NMR spectroscopy, mass spectrometry, and XRD analysis. |
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